Call for Proposal

We strongly encourage you to submit a proposal for discussion at the Annual Meeting to be held Thursday and Friday, November 3-4, 2016 at the NIH in Bethesda. The investigator initiated proposal sessions are a unique opportunity to receive valuable feedback from a peer of critical care researchers as well as network with NIH and Federal officials. A downloadable PDF of  this announcement can be found here: USCIIT 2016 CALL FOR PROPOSALS.

The Annual Meeting provides an opportunity for investigators to present clinical proposal in an inclusive and supportive environment. Consistent with the USCllT Group Code of Conduct, the success of this interaction is based upon a cooperative model of information exchange. The approach is inclusive and aims to learn from all those present. As the meeting is organizational, we expect that multidisciplinary “teams” will form that openly solicit input and encourage interdisciplinary collaboration among investigators with similar ideas across institutions.

The success of the US Critical Illness and Injury Trials (USCllT) Group is measured in part by the number of grant applications funded to study the critically ill or injured. To date, over 50 clinical projects have been presented. These projects generated several large research programs and received over $25 million in federal funding. The USCllT Group promotes clinical research and the application of new data to improve outcomes for the critical ill or injured across the developmental (age) continuum. To this end, it aims to establish an inclusive, nationwide network of experts to review published data, establish national priorities, vet hypotheses, write clinical protocols, and generate pilot data.

Please note that the trials group cannot provide funding or material resources. Instead, meeting attendees will provide feedback, volunteer service, collaborative input, and other forms of non-monetary support.

Examples of clinical proposals and the process may include but are not limited to the following:

  1. Testing a hypothesis at multiple centers: A Pl has convincing pilot data from a single institution suggesting that a new protocol/widget/drug may improve outcome/care for the critically ill or injured. Adequate power for a clinical trial of efficacy/effectiveness will require a large number of patients. USCllT collaborations are sought to collect and analyze additional preliminary data and to apply for grant funding to test the hypothesis at multiple centers.
  2. At a single institution, clinical equipoise exists for the use of an existing protocol/widget/drug. USCllT collaborators are sought to conduct a national survey, which in turn will motivate submission of a grant application to test the effectiveness of the protocol/widget/drug A versus B.
  3. Results from a seminal study have been validated prospectively in two subsequent, independent reports indicating that a new protocol/widget/drug improves outcome in a subpopulation of the critically ill or injured. The protocol/widget/drug is easy/cheap (or difficult/expensive) and interest exists in determining how best to implement it in clinical practice (efficacy versus effectiveness). USCllT input and collaborators are sought to generate new data, the analysis of which would be used to advise the community on dissemination of new research findings and implementation.
  4. Opportunity to present grant proposals (K, R-01) to clinical trialists for input prior to proposal submission. All project discussions are conducted under the USCllT Group Code of Conduct.

Submission Process

Clinical Proposals are limited to three pages in length. Each proposal must provide the following information:

  1. Project title
  2. Project Director(s) (Pl or co-Pl’s)
  3. Collaborators and their institutions
  4. Background
  5. Hypothesis
  6. Research design or plan
  7. Available resources (internal or preliminary funding, technical support, etc.)
  8. Funding goals
  9. Intellectual property restrictions or concerns 10. Expectations from USCllT Group

Clinical Proposals should be emailed by 5 pm EDT, September 16, 2016, to: usciit@email.arizona.edu

Proposals will be evaluated by the USCllT Group. Investigators will be notified of the status of their submission by October 3, 2016 for either poster presentation, or poster presentation and a brief PowerPoint presentation to the entire Group at the meeting.

Important Dates

Activity
September 16 Deadline for proposal submission
September 30 Notification of proposal selection
October 3 Investigators accept invitation
November 3-4

USCllT Annual Meeting in Bethesda Maryland

A downloadable PDF of  this announcement can be found here: USCIIT 2016 CALL FOR PROPOSALS.